|
ANTIINFLAMMATORY AND ANTIPYRETIC PROPERTIES OF THE RHIZOME OF COSTUS
SPECIOSUS (KOEN.) SM.
Binny K*1 Sunil Kumar G2 and
Dennis Thomas3
1Melmaruvathur Adhiparasakthi Institute of Medical
Sciences & Research, Melmaruvathur, Tamilnadu, India 2 Government
Medical College, Kottayam, Kerala, India3 Dr Reddy’s Laboratories
Ltd, Hyderabad, Andhra Pradesh, India
|
Date of Web Publication
|
15-Aug-2010
|
*Corresponding author:: Email: drbinnyk@gmail.com
 ABSTRACT
|
|
|
Rhizome of Costus speciosus has been traditionally used for treating inflammatory
and painful conditions. The objective of the present study was to provide a scientific
basis for the traditional use. The ethanolic extract of the rhizome of Costus speciosus
possesses anti-inflammatory and antipyretic properties. Antiinflammatory property
was studied in carrageenan induced paw edema and cotton pellet induced granuloma
formation. Significant antiinflammatory effect was found against carrageenan induced
edema formation in rats at a dose of 800 mg/kg and against cotton pellet granuloma
formation in rats at doses of 400 mg/kg and 800 mg/kg. The antipyretic property
was studied in yeast-induced pyrexia in rats. The antipyretic effect was only minimal
and was observed only at 800 mg/kg dose.
KEYWORDS: Screening methods, Paw edema, Cotton pellet granuloma, Pyrexia model,
Carrageenan
|