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SYNTHESIS AND BIOLOGICAL ACTIVITIES OF CERTAIN MESOIONIC SYDNONE
COMPOUNDS CONTAINING CHALCONE MOIETY
Shreenivas R. Deshpande*1 and K. Vasantakumar
Pai2
1Department of Medicinal and Pharmaceutical Chemistry,
HSK College of Pharmacy, BVVS Campus, Bagalkote-587 101, Karnataka, India
2Department of Medicine, Digestive Diseases and Nutrition Section, The
University of Oklahoma Department of Industrial Chemistry, Kuvempu University, Jnana
Sahyadri, Shankaraghatta-577 451, Shivamogga District, Karnataka, India
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Date of Web Publication
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15-Aug-2010
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*Correspondence Author: E-mail: srinidesh71@gmail.com
 Abstract
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In order to have antibacterial, analgesic and anti-inflammatory activity in the
same molecule, 4-[1-oxo-3- (substituted aryl)-2-propenyl]-3-(4-chlorophenyl)sydnones
were synthesized by condensing 4-acetyl-3-(4-chlorophenyl)sydnone with various substituted
aryl aldehydes and characterized by spectral studies; 4-acetyl-3-(4-chlorophenyl)sydnone
itself, was prepared by acetylation of 3-(4-chlorophenyl)sydnone. The newly synthesized
compounds were evaluated for antibacterial and anti-inflammatory activities by cup
plate and carrageenan induced rat paw edema methods respectively. Some of the compounds
showed promising antibacterial and anti-inflammatory activities.
KEYWORDS:Synthesis, sydnone, chalcone, antibacterial, anti-inflammatory
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